Effective and proper use of typography does make a difference in web design, as its over or improper use in web design can really have a negaitve impact on the whole website. Typography deals with the text related attributes like,
Not so long ago, designers tend to use small font size for text in web design, which often resulted in poor text readability. Now with the strong emergence of Web 2.0, designers have realized the fact that text is meant to be read and there is no point in adding text on website which is not readable.
Font type is another key attribute of text in web design which should be according to the message, target audience and overall layout of the website. Selecting wrong font type results in poor readability of text.
In web design few designers tend to use low-contrast text which looks good but does not read well. Poor text color selection can affect the overall look and feel of web design.